Delete system/pre-installed apps on a rooted device topic

Hi,

I'd like to know how to safely delete system or ROM pre-installed applications that don't offer an "Uninstall" option. I am rooted and running 5.0.2 on a Nexus 6. I know I could do this with Titanium or other similar apps but my point is to not install a specific app just for deleting apps if I can find the correct path/file from Root Explorer and remove it myself.

Thanks